The United States is challenging the ties that bind it as the main player in the global trading system, and there will be consequences if it pulls free.
Throughout history, the world's largest country by area has fallen back on the same strategy to maintain its economic stability: protectionism.
The West African giant has one of the most restrictive trade regimes in the world, thanks in large part to the abundant energy reserves on which it so heavily relies.
Although ASEAN's members often diverge on trade, they are united by the fact that they compete with other lower-end manufacturers for overseas markets and by their shared security and strategic interests.
The future of the small but wealthy European Free Trade Association is intertwined with that of its larger and better-known cousin, the European Union.
British industries are once again in flux as the world's fifth-largest economy prepares to leave the European Union.
The differing economic and political priorities of the country's provinces will add another wrinkle to international trade talks.
To keep the upper hand in its trade dealings, Beijing is determined to open up its economy at its own pace and on its own terms.
A central location offers the country its choice of regional trade partners. But diversifying its trade ties without sacrificing its relationship with the European Union will be a tricky task for Ankara.
The country understands that knitting itself ever more tightly into the global economy, whether through bilateral free trade agreements or through larger deals, is the only way it can overcome its isolation.
The bloc often bases its trade decisions around the diverging priorities of individual member states, each of which has its own history, identity and economic strengths.